Snakebites are a public health problem, especially in tropical countries.However, treatmentwith antivenomhas limited effectiveness\nagainst venoms� local effects. Here, we investigated the ability of Abarema cochliacarpos hydroethanolic extract (EAc) to protect\nmice against injection of Bothrops leucurus venom. Swiss mice received perimuscular venom injection and were subsequently\ntreated orally with EAc in different doses. Treatment with EAc 100, 200, and 400mg/kg reduced the edema induced by B. leucurus\nin 1%, 13%, and 39%, respectively. Although lower doses showed no antihypernociceptive effect in the Von Frey test, the higher\ndose significantly reduced hyperalgesia induced by the venom. Antimyotoxic activity of EAc was also observed by microscopy\nassessment, with treated muscles presenting preserved structures, decreased edema, and inflammatory infiltrate as compared to\nuntreated ones. Finally, on the rotarod test, the treated mice showed better motor function, once muscle fibers were preserved\nand there were less edema and pain. Treated mice could stand four times more time on the rotating rod than untreated ones. Our\nresults have shown that EAc presented relevant activities against injection of B. leucurus venom in mice, suggesting that it can be\nconsidered as an adjuvant in the treatment of envenomation.
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